FROM BIOINFORMATICS TO CLINICAL APPLICATIONS: A NOVEL PROGNOSTIC MODEL OF CUPROPTOSIS-RELATED GENES BASED ON SINGLE-CELL RNA SEQUENCING DATA IN HEPATOCELLULAR CARCINOMA

Abstract Objective and methods To ascertain the connection between cuproptosis-related genes (CRGs) and the prognosis of hepatocellular carcinoma (HCC) via single-cell RNA sequencing (scRNA-seq) and RNA sequencing (RNA-seq) data, relevant data were downloaded from the GEO and TCGA databases.The differentially expressed CRGs (DE-CRGs) were filtered

Venous air embolism (VAE) is the air bubble Popcorn accumulation in the right side of the heart, or in the pulmonary region.Pre-cordial Doppler allows a real-time monitoring of heart sound and is used to detect VAE episodes through changes in cardiac sound.Sometimes these changes are not detected by the operator, which reveals the importance of fin

Scrub typhus is a vector-borne, acute febrile illness caused by Orientia tsutsugamushi.Scrub typhus continues to be an important but neglected tropical disease in Nepal.Information on this pathogen in Nepal is limited to serological surveys with little information available on molecular methods to detect O.tsutsugamushi.Limited information exists o

Mechanical ventilation is used to improve gas exchange and unload the respiratory muscles allowing Stroller organiser for their rest and recovery, which require good synchronization between the patient and the ventilator.Spontaneous respiratory effort is generally preferred because it reduces atelectasis, improves oxygenation, and may prevent disus

Carbon nanotubes are a new class of microtubule-stabilizing agents since they interact with protein microtubules in living cells, interfering with cell division and inducing apoptosis.In the present work, a modified beam model is developed to investigate the effect of carbon nanotubes on the buckling of microtubule bundles in living cell.A realisti